Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.
نویسندگان
چکیده
Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.
منابع مشابه
Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: a case report.
OBJECTIVES Linezolid is an oxazolidinone antibiotic used in the treatment of infections caused by vancomycin-resistant enterococci. Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. PATIENT AND METHODS We present clinical details and susceptibility data from multiple Enterococcus faecium strains isolated from a liver transplant patient over 13 mon...
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Sir, Worldwide, antimicrobial resistance among the Grampositive cocci is increasing. In South East Asia, multidrug resistance among Staphylococcus aureus and Streptococcus pneumoniae is particularly problematic. At present, vancomycin-resistant enterococci (VRE) are uncommon in this region, but clusters have been reported. Our previous study and those of others showed that susceptibility of dru...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 6 شماره
صفحات -
تاریخ انتشار 2008